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  1. The regulatory roles of circular RNAs (circRNAs) in tumorigenesis have attracted increasing attention. However, novel circRNAs with the potential to be used as serum/plasma biomarkers and their regulatory mech...

    Authors: Lianghai Wang, Lisha Zhou, Jun Hou, Jin Meng, Ke Lin, Xiangwei Wu and Xueling Chen

    Citation: Cancer Cell International 2021 21:72

    Content type: Primary research

    Published on:

  2. Recent studies have established the roles of microRNAs (miRNAs) in cancer progression. The aberrant expression of miR-335-5p has been reported in many cancers, including gastric cancer (GC). In this study, the...

    Authors: Yi Gao, Yanfeng Wang, Xiaofei Wang, Changan Zhao, Fenghui Wang, Juan Du, Huahua Zhang, Haiyan Shi, Yun Feng, Dan Li, Jing Yan, Yan Yao, Weihong Hu, Ruxin Ding, Mengjie Zhang, Lumin Wang…

    Citation: Cancer Cell International 2021 21:71

    Content type: Primary research

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  3. Gastric cancer is one of the most prevalent and deadly malignancies without efficient treatment option. This study aimed to investigate the effect of hydrogen gas on the behavior of gastric cancer cells.

    Authors: Baocheng Zhu, Hengguan Cui and Weiqiang Xu

    Citation: Cancer Cell International 2021 21:70

    Content type: Primary research

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  4. Colorectal cancer (CRC) is among the deadliest cancers, wherein early dissemination of tumor cells, and consequently, metastasis formation, are the main causes of mortality and poor prognosis. Cofilin-1 (CFL-1...

    Authors: Annie Cristhine Moraes Sousa-Squiavinato, Renata Ivo Vasconcelos, Adriana Sartorio Gehren, Priscila Valverde Fernandes, Ivanir Martins de Oliveira, Mariana Boroni and Jose Andrés Morgado-Díaz

    Citation: Cancer Cell International 2021 21:69

    Content type: Primary research

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  5. MicroRNAs (miRNAs) and long non-coding RNAs (lncRNAs) could interact with each other to play a vital role in the pathogenesis of cancers. We aimed to examine the expression profile, clinical significance and r...

    Authors: Jingjing Jing, Xu Zhao, Jiannan Wang and Tan Li

    Citation: Cancer Cell International 2021 21:68

    Content type: Primary research

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  6. Bladder cancer (BCa) is a malignant tumor that occurs on the mucosa of the bladder, in which dysregulated long non-coding RNAs (lncRNAs) are involved. This study investigated the effect of lncRNA small nucleol...

    Authors: Rui Feng, Zhongxing Li, Xing Wang, Guangcheng Ge, Yuejun Jia, Dan Wu, Yali Ji and Chenghao Wang

    Citation: Cancer Cell International 2021 21:67

    Content type: Primary research

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  7. Gastric cancer (GC) is one of the most common cancers with high malignancy. In spite of the great development in diagnostic tools and application of anti-tumor drugs, we have not witnessed a significant increa...

    Authors: Milad Ashrafizadeh, Hossein Rafiei, Reza Mohammadinejad, Tahereh Farkhondeh and Saeed Samarghandian

    Citation: Cancer Cell International 2021 21:66

    Content type: Review

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  8. Lung cancer is the most common malignant tumor. Identification of novel diagnostic and prognostic biomarkers for lung cancer is a key research imperative. The role of centromere protein K (CENPK) in cancer is ...

    Authors: Jiayu Ma, Xiaochuan Chen, Mingqiang Lin, Zhiping Wang, Yahua Wu and Jiancheng Li

    Citation: Cancer Cell International 2021 21:65

    Content type: Primary research

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  9. Hedgehog (Hh) signaling pathway, which is essential for cell proliferation and differentiation, is noted to be aberrantly activated in tumor from increasing studies in recent years. MicroRNAs (miRNAs) as an im...

    Authors: Jiong Ma, Chunxia Zhou and Xuejun Chen

    Citation: Cancer Cell International 2021 21:64

    Content type: Primary research

    Published on:

  10. Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) can induce substantial cytotoxicity in tumor cells but rarely exert cytotoxic activity on non-transformed cells. In the present study, we therefo...

    Authors: Shihai Liu, Jing Qiu, Guifang He, Weitai He, Changchang Liu, Duo Cai and Huazheng Pan

    Citation: Cancer Cell International 2021 21:63

    Content type: Primary research

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  11. Hypoxia is a common feature of solid tumors, and develops because of the rapid growth of the tumor that outstrips the oxygen supply, and impaired blood flow due to the formation of abnormal blood vessels suppl...

    Authors: Asieh Emami Nejad, Simin Najafgholian, Alireza Rostami, Alireza Sistani, Samaneh Shojaeifar, Mojgan Esparvarinha, Reza Nedaeinia, Shaghayegh Haghjooy Javanmard, Marjan Taherian, Mojtaba Ahmadlou, Rasoul Salehi, Bahman Sadeghi and Mostafa Manian

    Citation: Cancer Cell International 2021 21:62

    Content type: Review

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  12. Studies have shown the value of subtypes and distribution of gastric intestinal metaplasia (GIM) for prediction of gastric cancer. We aim to combine GIM subtypes and distribution to form a new scoring system f...

    Authors: Ning Wei, Zhiheng Zhong and Ruihua Shi

    Citation: Cancer Cell International 2021 21:61

    Content type: Primary research

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  13. Interferon regulatory factor 4 (IRF4) is a transcription factor from the IRF factor family that exerts regulatory functions in the immune system and oncogenesis. However, the biological role of IRF4 in colon c...

    Authors: Jiwei Wang, Song Li, Honglang Li, Xiaoshuang Zhou, Huabin Wen and Bin Lai

    Citation: Cancer Cell International 2021 21:58

    Content type: Primary research

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  14. Drug resistance and metastasis involving hypoxic tumor environments and persistent stem cell populations are detrimental to the survival of patients with non-small cell lung carcinoma (NSCLC). Tie1 is upregula...

    Authors: Chaojie Li, Nannan Yang, Zhijin Chen, Ning Xia, Qungang Shan, Ziyin Wang, Jian Lu, Mingyi Shang and Zhongmin Wang

    Citation: Cancer Cell International 2021 21:57

    Content type: Primary research

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  15. Increasing evidence has demonstrated that snoRNAs play crucial roles in tumorigenesis of various cancer types. However, researches on snoRNAs in ccRCC were very little. This study mainly aimed to validate the ...

    Authors: Xiaoling Shang, Xingguo Song, Kangyu Wang, Miao Yu, Shanshan Ding, Xiaohan Dong, Li Xie and Xianrang Song

    Citation: Cancer Cell International 2021 21:56

    Content type: Primary research

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  16. Resistance to drug therapy is a major impediment for successful treatment of patients suffering from breast cancer (BC). Tamoxifen (TAM) is an extensively used therapeutic agent, which substantially reduces th...

    Authors: Jianhui Liu, Shaoliang Zhu, Wei Tang, Qinghua Huang, Yan Mei and Huawei Yang

    Citation: Cancer Cell International 2021 21:55

    Content type: Primary research

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  17. Increasing evidence manifested that circular RNAs (circRNAs) acted as crucial regulators in human cancers by targeting the miRNA/mRNA axis, including cervical cancer (CC). Circ_0007534 was reported to promote ...

    Authors: Qiang Sun, Xiangying Qi, Wenyan Zhang and Xiaoyu Li

    Citation: Cancer Cell International 2021 21:54

    Content type: Primary research

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  18. Acute myeloid leukemia (AML) remains a devastating disease with a 5-year survival rate of less than 30%. AML treatment has undergone significant changes in recent years, incorporating novel targeted therapies ...

    Authors: May Levin, Michal Stark, Yishai Ofran and Yehuda G. Assaraf

    Citation: Cancer Cell International 2021 21:53

    Content type: Primary research

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  19. Osteosarcoma (OS) is a malignant tumor of the bone mostly observed in children and adolescents. The current treatment approach includes neoadjuvant and adjuvant chemotherapy; however, drug resistance often hin...

    Authors: Heena Saini, Harshita Sharma, Sudeshna Mukherjee, Shibasish Chowdhury and Rajdeep Chowdhury

    Citation: Cancer Cell International 2021 21:52

    Content type: Primary research

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  20. It has been reported that the lncRNA SNHG16 has significantly increased expression in pancreatic adenocarcinoma (PC). However, the functions and mechanisms of SNHG16 are not clear. The aim of this study was to...

    Authors: Hao Xu, Xin Miao, Xin Li, Haofei Chen, Bo Zhang and Wence Zhou

    Citation: Cancer Cell International 2021 21:51

    Content type: Primary research

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  21. The exosomal nucleic acid (exoNA) from the plasma and pleural fluid can potentially provide means to identify genomic changes in non-small cell lung cancer (NSCLC) patients who develop resistance to targeted e...

    Authors: Yoonjung Kim, Saeam Shin and Kyung-A Lee

    Citation: Cancer Cell International 2021 21:50

    Content type: Primary research

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  22. Serum Deprivation Protein Response (SDPR) plays an important role in formation of pulmonary alveoli. However, the functions and values of SDPR in lung cancer remain unknown. We explored prognostic value, expre...

    Authors: Xiaoqing Luo, Shunli Peng, Sijie Ding, Qin Zeng, Rong Wang, Yueyun Ma, ShiYu Chen, Yanxia Wang and Wei Wang

    Citation: Cancer Cell International 2021 21:49

    Content type: Primary research

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  23. Cell division cycle associated 4 (CDCA4) has been reported to be engaged into the progression of several cancers. The function of CDCA4 in Non-small cell lung cancer (NSCLC) was unknown. We aimed to explore th...

    Authors: Chenxin Xu, Haixia Cao, Ying Sui, Hui Zhang, Chen Shi, Jianzhong Wu, Rong Ma and Jifeng Feng

    Citation: Cancer Cell International 2021 21:48

    Content type: Primary research

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  24. METTL14, as one of N6-methyladenosine (m6A) related genes, has been found to be associated with promoting tumorigenesis in different types of cancers. This study was aimed to investigate the prognostic value o...

    Authors: Yi Wang, Rong Cong, Shouyong Liu, Bingye Zhu, Xing Wang and Qianwei Xing

    Citation: Cancer Cell International 2021 21:46

    Content type: Primary research

    Published on:

  25. Gastric cancer (GC) is one of the most common cancers in the world. Due to the lack of specific symptoms, more than 80% of patients are diagnosed as the advanced stage with a high mortality rate, so the early ...

    Authors: Shuo Ma, Shan Kong, Xinliang Gu, Yanhua Xu, Mei Tao, Lei Shen, Xianjuan Shen and Shaoqing Ju

    Citation: Cancer Cell International 2021 21:44

    Content type: Primary research

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  26. Ectopic expression of transcription elongation factor A (SII)-like 7 (TCEAL7) has been observed in several kinds of cancers, but its role in melanoma is still unclear. This study was carried out to investigate...

    Authors: Xilin Liu, Xianji Song and Hong Li

    Citation: Cancer Cell International 2021 21:43

    Content type: Primary research

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  27. Clinical management of triple-negative breast cancer (TNBC) patients remain challenging because of the development of chemo-resistance. Identification of biomarkers for risk stratification of chemo-resistance ...

    Authors: Shan Zhu, Yulin Xu, Lijun Wang, Shichong Liao, Yuan Wang, Manman Shi, Yi Tu, Yurong Zhou and Wen Wei

    Citation: Cancer Cell International 2021 21:42

    Content type: Primary research

    Published on:

  28. Renal cell carcinoma (RCC) is a clinically common tumor in the urinary system, showing an upward trend of both incidence and mortality. Apolipoprotein C1 (APOC1) has been identified as a vital regulator in tum...

    Authors: Hao Jiang, Jing-Yuan Tang, Dong Xue, Yi-Meng Chen, Ting-Chun Wu, Qian-Feng Zhuang and Xiao-Zhou He

    Citation: Cancer Cell International 2021 21:41

    Content type: Primary research

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  29. This article has been retracted. Please see the Retraction Notice for more detail: https://0-doi-org.brum.beds.ac.uk/10.1186/s12935-021-01759-5.

    Authors: Jin Gao, Yuan Yuan, Lili Zhang, Shaorong Yu, Jianwei Lu, Jifeng Feng and Sainan Hu

    Citation: Cancer Cell International 2021 21:40

    Content type: Retraction Note

    Published on:

    The original article was published in Cancer Cell International 2020 20:90

  30. LncRNA HOXA-AS2 has been found in the literature to deteriorate glioblastoma. However, its regulatory mechanism is yet to be fully investigated. Our study focused chiefly on the interaction and role of the HOX...

    Authors: Jixin Shou, Haidong Gao, Sen Cheng, Bingbing Wang and Haibo Guan

    Citation: Cancer Cell International 2021 21:39

    Content type: Primary research

    Published on:

  31. Breast cancer is the first killer leading to female death, and tumor metastasis is one of the important factors leading to the death of patients, but the specific mechanism of breast cancer metastasis is not v...

    Authors: Bowen Li, Liying Mu, Yanan Li, Kangkai Xia, Yuxi Yang, Sattout Aman, Bashir Ahmad, Shujing Li and Huijian Wu

    Citation: Cancer Cell International 2021 21:38

    Content type: Primary research

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  32. Oral squamous cell carcinoma (OSCC) has been one of the most malignant cancers in head and neck region. Anlotinib is a tyrosine kinase inhibitor targeting several receptors such as vascular endothelial growth ...

    Authors: Zhaoming Deng, Wei Liao, Wei Wei, Guihua Zhong, Chao He, Hongbo Zhang, Qiaodan Liu, Xiwei Xu, Jun Liang and Zhigang Liu

    Citation: Cancer Cell International 2021 21:37

    Content type: Primary research

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  33. Long non-coding RNAs (lncRNAs) are pervasively transcribed in genome and emerging as a new player in tumorigenesis due to their functions in transcriptional, posttranscriptional and epigenetic mechanisms of ge...

    Authors: Min Hou, Nannan Wu and Lili Yao

    Citation: Cancer Cell International 2021 21:36

    Content type: Primary research

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  34. The incidence rates of cervical cancer in developing countries have been steeply increasing while the medical resources for prevention, detection, and treatment are still quite limited. Computer-based deep lea...

    Authors: Xiangyu Tan, Kexin Li, Jiucheng Zhang, Wenzhe Wang, Bian Wu, Jian Wu, Xiaoping Li and Xiaoyuan Huang

    Citation: Cancer Cell International 2021 21:35

    Content type: Primary research

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  35. Emerging evidence suggested that long intergenic noncoding RNA (lincRNA) 00887 (NR_024480) reduced the invasion and metastasis of non-small cell lung cancer by sponging miRNAs degradation. However, the role an...

    Authors: Pei Li, Jinsheng Wang, Lingran Zhi and Fengmei Cai

    Citation: Cancer Cell International 2021 21:33

    Content type: Primary research

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  36. Triple-negative breast cancer (TNBC) is the most challenging breast cancer subtype to treat, because it is so aggressive with shorter survival. Chemotherapy remains the standard treatment due to the lack of sp...

    Authors: Yuanyuan Cheng, Lishuang Lin, Xiaoyan Li, Aiqi Lu, Chenjian Hou, Qian Wu, Xiaomu Hu, Zhongwen Zhou, Zhongqing Chen and Feng Tang

    Citation: Cancer Cell International 2021 21:32

    Content type: Primary research

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  37. Autophagy is a double-edged sword during the initiation and progression of multiple tumors. The Hippo pathway effector YAP has been proved to be involved in autophagy processes. The present study aimed to inve...

    Authors: Wei Xu, Mingjiong Zhang, Yue Li, Yu Wang, Kai Wang, Qiaoyu Chen, Runjie Zhang, Weiwei Song, Qiqing Huang, Weihong Zhao and Jianqing Wu

    Citation: Cancer Cell International 2021 21:30

    Content type: Primary research

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  38. Endometrial cancer is an invasive gynecological cancer prevalent in the world. The pathogenesis of endometrial cancer is related to multiple levels of regulation, referring to oestrogen, tumor-suppressor gene ...

    Authors: Yue Chang, Min Hao, Ru Jia, Yihui Zhao, Yixuan Cai and Yun Liu

    Citation: Cancer Cell International 2021 21:29

    Content type: Primary research

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  39. Circular RNAs (circRNAs) is a newly discovered type of non-coding RNA, the abnormal expression of which has been demonstrated in many types of human tumors. So they have been considered as promising candidates...

    Authors: Jing Han, Nannan Han, Zhimin Xu, Chunye Zhang, Jiannan Liu and Min Ruan

    Citation: Cancer Cell International 2021 21:28

    Content type: Primary research

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  40. Increasing studies have revealed that circular RNAs (CircRNAs) make great contributions to regulating tumor progression. Therefore, we intended to explore the expression characteristics, function, and related ...

    Authors: Kebin Zheng, Haipeng Xie, Wensong Wu, Xichao Wen, Zhaomu Zeng and Yanfang Shi

    Citation: Cancer Cell International 2021 21:27

    Content type: Primary research

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  41. TCAB1, a.k.a. WRAP53β or WDR79, is an important molecule for the maintenance of Cajal bodies and critically involved in telomere elongation and DNA repair. Upregulation of TCAB1 were discovered in a variety ty...

    Authors: Jing Niu, Rui-Qi Gao, Meng-Tian Cui, Chen-Guang Zhang, Shen-Tao Li, Shan Cheng and Wei Ding

    Citation: Cancer Cell International 2021 21:26

    Content type: Primary research

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  42. Cervical cancer is one most common cancer types among females over the world. While its underlying mechanisms remain unclear. Circ-CCDC66 has been revealed to participate in multiple biological functions, and ...

    Authors: Yan Zhang, Xing Li, Jun Zhang and Lin Mao

    Citation: Cancer Cell International 2021 21:20

    Content type: Primary research

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  43. Non-small cell lung cancers (NSCLC) account for most cases of lung cancer. More effort is needed to research new drug and combination therapies for this disease. An anthraquinone derivative, emodin shows antic...

    Authors: Mingzhu Li, Shengbo Jin, Yang Cao, Jian Xu, Shendong Zhu and Zheng Li

    Citation: Cancer Cell International 2021 21:19

    Content type: Primary research

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  44. Duodenal papilla carcinoma (DPC) is a rare malignancy of the gastrointestinal tract with high recurrence rate, and the pathogenesis of this highly malignant neoplasm is yet to be fully elucidated. This study a...

    Authors: Yuanxiang Lu, Wensen Li, Ge Liu, Yongbo Yang, Erwei Xiao, Senmao Mu, Yuqi Guo, Deyu Li and Guoyi Yan

    Citation: Cancer Cell International 2021 21:9

    Content type: Primary research

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  45. Endometrial carcinoma is a frequently diagnosed cancer among females. LncRNAs are reported to be associated with various cancers. Their biological roles in endometrial carcinoma progression is an emerging scie...

    Authors: Yixuan Cai, Min Hao, Yue Chang and Yun Liu

    Citation: Cancer Cell International 2021 21:8

    Content type: Primary research

    Published on:

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