Table 2 Kyoto Encyclopedia of Genes and Genomes pathway analysis of aberrantly methylated differentially expressed genes in prostate cancer
Category | Term | Count | P value | Gene |
|---|---|---|---|---|
Hypomethylated with high expression | ||||
 KEGG_PATHWAY | hsa04152: AMPK signalling pathway | 12 | 0.0025 | AKT1, IGF1R, PDPK1, IRS2, CCND1, TSC2, ACACA, FASN, FBP1, EEF2, PPP2R2D, RPTOR |
 KEGG_PATHWAY | hsa05200: pathways in cancer | 24 | 0.0062 | HSP90AB1, DVL3, CTBP1, ADCY1, COL4A1, ADCY7, RXRA, CREBBP, GNA12, LEF1, FZD4, TCF7L2, TPM3, DAPK1, AKT1, JUP, IGF1R, WNT7B, CBLB, CCND1, GNB2, GNB1, CASP8, GNG7 |
 KEGG_PATHWAY | hsa04520: adherens junction | 8 | 0.0094 | ACTG1, IGF1R, TJP1, WASF3, BAIAP2, CREBBP, LEF1, TCF7L2 |
Hypermethylated with low expression | ||||
 KEGG_PATHWAY | hsa05412: arrhythmogenic right ventricular cardiomyopathy (ARVC) | 8 | 3.99E−04 | DES, SGCG, DMD, ITGA7, ITGA1, CACNB2, GJA1, CTNNB1 |
 KEGG_PATHWAY | hsa04510: focal adhesion | 12 | 0.0020 | CAV2, ITGA7, ITGA1, PDGFC, PTEN, FLNA, PIK3R1, MYLK, COL4A6, KDR, CTNNB1, PRKCB |
 KEGG_PATHWAY | hsa05410: hypertrophic cardiomyopathy (HCM) | 7 | 0.0038 | DES, SGCG, DMD, ITGA7, ITGA1, CACNB2, TPM1 1 |
 KEGG_PATHWAY | hsa05414: dilated cardiomyopathy | 7 | 0.0054 | DES, SGCG, DMD, ITGA7, ITGA1, CACNB2, TPM1 |
 KEGG_PATHWAY | hsa04151: PI3K-Akt signalling pathway | 15 | 0.0063 | FGFR2, ITGA1, KITLG, KIT, LPAR1, PTEN, COL4A6, KDR, EIF4B, CDKN1B, ITGA7, ANGPT1, PDGFC, FGF2, PIK3R1 |