Roles of β-catenin, TCF-4, and survivin in nasopharyngeal carcinoma: correlation with clinicopathological features and prognostic significance

Table 4 Correlations of expressions of β-catenin, TCF-4 and survivin with clinicopathological features of NPC

Clinicopathological features	n	β-catenin				TCF-4				Survivin
Clinicopathological features	n	−	+	Positive rate	P	−	+	Positive rate	P	−	+	Positive rate	P
Age
≤ 45	86	27	59	0.69	0.166	26	60	0.7	0.64	29	57	0.66	0.345
> 45	78	17	61	0.78	0.166	21	57	0.73	0.64	21	57	0.73	0.345
Gender
Male	117	28	89	0.76	0.186	32	85	0.73	0.559	32	85	0.73	0.169
Female	47	16	31	0.66	0.186	15	32	0.68	0.559	18	29	0.62	0.169
Smoking history
Yes	107	24	83	0.78	0.082	32	75	0.7	0.628	32	75	0.7	0.825
No	57	20	37	0.65	0.082	15	42	0.74	0.628	18	39	0.68	0.825
Family history
Yes	95	23	83	0.87	0.193	27	68	0.72	0.937	26	69	0.73	0.309
No	69	21	48	0.7	0.193	20	49	0.71	0.937	24	45	0.65	0.309
EBV DNA
Positive	116	15	101	0.87	<0.001	24	92	0.79	0.001	27	89	0.77	0.002
Negative	48	29	19	0.40	<0.001	23	25	0.52	0.001	23	25	0.52	0.002
EBV-VCA-IgA
Positive	111	21	90	0.81	0.001	22	89	0.80	<0.001	28	83	0.75	0.034
Negative	53	23	30	0.57	0.001	25	28	0.53	<0.001	22	31	0.58	0.034
EBV-EA-IgA
Positive	64	4	60	0.94	<0.001	5	59	0.92	<0.001	7	57	0.89	<0.001
Negative	100	40	60	0.60	<0.001	42	58	0.58	<0.001	43	57	0.57	<0.001
T stage
T1	28		4	0.14	<0.001	18	10	0.36	<0.001	16	12	0.43	0.004
T2	52	16	36	0.69		12	40	0.77		19	33	0.63
T3	48	2	46	0.96		15	33	0.69		13	35	0.73
T4	36	2	34	0.94		2	34	0.94		2	34	0.94
N stage
N0	27	25	2	0.07	<0.001	20	7	0.26	<0.001	16	11	0.41	0.006
N1	41	17	24	0.59		11	30	0.73		18	23	0.56
N2	47	1	46	0.98		9	38	0.81		8	39	0.83
N3	49	24	48	0.98		7	42	0.86		8	41	0.84
Clinicopathological stages
I	19	16	3	0.16	<0.001	13	6	0.32	0.002	12	7	0.37	0.021
II	22	10	12	0.55		13	9	0.41		11	11	0.5
III	35	10	25	0.71		8	27	0.77		10	25	0.71
IVa	49	6	43	0.88		8	41	0.84		12	37	0.76
IVb	39	2	37	0.95		5	34	0.87		5	34	0.87
Histological classification
Differentiated non-keratinized	113	27	86	0.76	0.207	31	82	0.73	0.606	32	81	0.72	0.370
Undifferentiated non-keratinized	51	17	34	0.67	0.207	16	35	0.69	0.606	18	33	0.65	0.370

The standard of family history of nasopharyngeal carcinoma was at least two or more NPC patients in the two generation, and is the first-degree relatives. The standard of smoking history was to smoke one cigarette every day for 6 months or more
TCF-4 T-cell factor-4, NPC nasopharyngeal carcinoma, T tumor, N node, + positive expression, − negative expression

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