Fig. 6

miR-330-5p down-regulates the expression of LDOC1 thus promoting proliferation and metastasis of cervical cancer cells. a Transfection efficiency in HeLa cells tested by RT-qPCR. b HeLa cell viability detected by CCK-8 assay. c HeLa cell invasion and migration detected by Transwell assay. d The expression of proliferation-related proteins Ki-67, PCNA, migration-related proteins N-cad, E-cad and invasion-related proteins MMP-2 and MMP-9 in HeLa cells determined by Western blot analysis. *p < 0.05 vs. cells treated with NC inhibitor and sh-NC; ^#p < 0.05 vs. cells transfected with miR-330-5p inhibitor and sh-NC. The data of each group were measurement data, expressed as mean ± standard deviation. One-way analysis of variance was used for comparison among multiple groups followed by Tukey’s post hoc test. The experiment was conducted three times