Table 2 Univariable and multivariable Cox regression model analyses of cause-specific survival in nomogram cohort

Gender

0.002

0.066

 Female

1

1

 Male

0.909

0.857–0.965

1.058

0.965–1.054

Race

0.985

 White

1

 Other^a

1.001

0.907–1.105

Year of diagnosis

0.445

 2010–2012

1

 2013–2015

0.976

0.915–1.040

Age at diagnosis

< 0.001

< 0.001

 < 60

1

1

 ≥ 60

1.913

1.781–2.056

1.718

1.591–1.856

Tumor site

< 0.001

0.003

 Right

1

1

 Left

0.825

0.778–0.875

0.912

0.857–0.970

Histological subtype

< 0.001

0.001

 AD

1

1

 MAD

1.251

1.135–1.378

< 0.001

0.983

0.891–1.085

0.738

 SRCC

4.042

3.368–4.851

< 0.001

1.444

1.195–1.746

< 0.001

Pathological grade

< 0.001

< 0.001

 Grade I

1

1

 Grade II

1.447

1.259–1.664

< 0.001

1.080

0.939–1.243

0.282

 Grade III

2.867

2.477–3.319

< 0.001

1.350

1.162–1.568

< 0.001

 Grade IV

3.704

3.091–4.439

< 0.001

1.650

1.372–1.984

< 0.001

T stage

< 0.001

< 0.001

 T1

1

1

 T2

2.022

1.590–2.573

< 0.001

1.741

1.366–2.218

< 0.001

 T3

5.497

4.429–6.822

< 0.001

3.579

2.864–4.472

< 0.001

 T4a

14.594

11.686–18.226

< 0.001

7.283

5.775–9.186

< 0.001

 T4b

17.479

13.929–21.933

< 0.001

9.477

7.467–12.029

< 0.001

N stage

< 0.001

< 0.001

 N0

1

1

 N1

2.418

2.257–2.591

< 0.001

2.090

1.774–2.461

< 0.001

 N2

4.679

4.437–5.125

< 0.001

3.220

2.678–3.872

< 0.001

Chemotherapy

< 0.001

< 0.001

 No

1

1

 Yes

1.142

1.076–1.213

0.498

0.465–0.534

LNH

< 0.001

< 0.001

 < 12

1

1

 ≥ 12

0.669

0.617–0.726

0.582

0.535–0.634

LODDS stage

< 0.001

< 0.001

 LODDS 1

1

1

 LODDS 2

2.689

2.528–2.861

< 0.001

1.290

1.097–1.517

0.002

 LODDS 3

7.359

6.64–8.156

< 0.001

2.005

1.647–2.442

< 0.001

 LODDS 4

21.948

16.814–28.649

< 0.001

4.274

3.109–5.876

< 0.001

Tumor size

< 0.001

0.038

 < 4

1

1

 ≥ 4

1.781

1.671–1.899

1.075

1.004–1.152

CEA

< 0.001

< 0.001

 Negative

1

1

 Positive

2.292

2.163–2.429

1.575

1.484–1.671

Marriage status

< 0.001

< 0.001

 Married

1

1

 Single

1.323

1.199–1.459

< 0.001

1.197

1.085–1.321

< 0.001

 Separated/Divorced

1.397

1.285–1.519

< 0.001

1.298

1.193–1.493

< 0.001

 Widowed

2.084

1.937–2.243

< 0.001

1.470

1.362–1.587

< 0.001