ZKSCAN3 drives tumor metastasis via integrin β4/FAK/AKT mediated epithelial–mesenchymal transition in hepatocellular carcinoma

Table 1 Clinical correlation of ZKSCAN3 expression in HCC (n = 101)

Clinical parameters	Cases (n)	Expression level		P value (*P < 0.05)
Clinical parameters	Cases (n)	ZKSCAN3^high (n = 51)	ZKSCAN3^low (n = 50)	P value (*P < 0.05)
Age (years)
< 60 years	65	35	30	0.365
≥ 60 years	36	16	20
Gender
Male	80	39	41	0.494
Female	21	12	9
Tumor size (cm)				0.140
< 5 cm	72	33	39
≥ 5 cm	29	18	11
Tumor number				0.199
Solitary	84	40	44
Multiple	17	11	6
Edmondson				0.215
I + II	23	9	14
III + IV	78	42	36
TNM stage				0.013*
I + II	76	33	43
III + IV	25	18	7
Vascular infiltration				0.007*
Present	16	13	3
Absent	85	38	47
AFP				0.601
< 400 ng/ml	24	11	13
≥ 400 ng/ml	77	40	37
HBsAg				0.527
Positive	91	45	46
Negative	10	6	4

HCC hepatocellular carcinoma, AFP alpha-fetoprotein, TNM tumor-node-metastasis
* Statistically significant

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