Fig. 2

Down-regulation of circ_0007534 repressed CC cell growth and invasion but facilitated apoptosis. a The qRT-PCR indicated that the interference efficiency of si-circ_0007534 was successful. b, c MTT displayed that si-circ_0007534 suppressed cell viability in SiHa (b) and HeLa (c) cells contrasted to si-NC. d, e Colony formation assay exhibited that si-circ_0007534 reduced cell proliferation contrasted to si-NC. f, g Flow cytometry demonstrated that si-circ_0007534 enhanced cell apoptosis contrasted to si-NC. h, i Western blot for apoptotic protein detection confirmed that cell apoptosis was promoted by si-circ_0007534 compared with si-NC. j, k Transwell assay suggested that cell invasion was inhibited by si-circ_0007534 compared with si-NC. NC negative control, OD optical density, Bcl-2 B-cell lymphoma-2, Bax Bcl-2-Associated X, C-Caspase3 Cleaved-Caspase3, GAPDH glyceraldehyde-phosphate dehydrogenase. All assays were performed for three times with technical n = 3. Statistical analysis was conducted by Student’s t-test. *P < 0.05, **P < 0.01, ***P < 0.001