Effects of in IL-1B/IL-1RN variants on the susceptibility to head and neck cancer in a chinese Han population

Yin, Yanhai; Li, Fen; Tong, Liangqian; Chen, Chunru; Yuan, Bo

doi:10.1186/s12935-021-01750-0

Cancer Cell International

Table 3 The effect of genetic variants in IL-1B/IL-1RN on the susceptibility to head and neck cancer

From: Effects of in IL-1B/IL-1RN variants on the susceptibility to head and neck cancer in a chinese Han population

Gene	SNP ID	Model	Genotype	Case	Control	Adjusted by age and gender
Gene	SNP ID	Model	Genotype	Case	Control	OR (95% CI)	p
IL-1B	rs1143643	Genotype	CC	114	146	1
			CT	277	272	1.30 (0.97–1.75)	0.080
			TT	144	120	1.54 (1.09–2.17)	0.015*
		Dominant	CC	114	146	1
			CT-TT	421	392	1.38 (1.04–1.82)	0.026*
		Recessive	CC-CT	391	418	1
			TT	144	120	1.28 (0.97–1.70)	0.080
		Log-additive				1.24 (1.04–1.47)	0.015*
IL-1B	rs1143630	Genotype	GG	378	378	1
			GT	140	147	0.95 (0.73–1.25)	0.736
			TT	17	13	1.31 (0.63–2.74)	0.473
		Dominant	GG	378	378	1
			GT-TT	157	160	0.98 (0.76–1.28)	0.898
		Recessive	GG-GT	518	525	1
			TT	17	13	1.33 (0.64–2.76)	0.449
		Log-additive				1.02 (0.81–1.28)	0.898
IL-1B	rs1143627	Genotype	GG	118	139	1
			GA	278	266	1.23 (0.91–1.66)	0.171
			AA	139	131	1.25 (0.89–1.76)	0.201
		Dominant	GG	118	139	1
			GA-AA	417	397	1.24 (0.93–1.64)	0.138
		Recessive	GG-GA	396	405	1
			AA	139	131	1.09 (0.82–1.43)	0.559
		Log-additive				1.12 (0.94–1.33)	0.205
IL-1B	rs16944	Genotype	AA	116	139	1
			AG	276	265	1.25 (0.93–1.68)	0.146
			GG	143	133	1.29 (0.92–1.81)	0.146
		Dominant	AA	116	139	1
			AG-GG	419	398	1.26 (0.95–1.67)	0.107
		Recessive	AA-AG	392	404	1
			GG	143	133	1.11 (0.84–1.46)	0.462
		Log-additive				1.13 (0.96–1.34)	0.151
IL-1RN	rs17042888	Genotype	GG	310	281	1
			GA	191	222	0.78 (0.61–1.00)	0.053
			AA	34	35	0.88 (0.54–1.45)	0.622
		Dominant	GG	310	281	1
			GA-AA	255	257	0.79 (0.62–1.01)	0.060
		Recessive	GG-GA	501	503	1
			AA	34	35	0.98 (0.60–1.59)	0.925
		Log-additive				0.86 (0.70–1.04)	0.119
IL-1RN	rs315919	Genotype	TT	204	189	1
			TG	261	258	0.94 (0.72–1.22)	0.627
			GG	70	91	0.71 (0.49–1.03)	0.072
		Dominant	TT	204	189	1
			TG-GG	331	349	0.88 (0.69–1.13)	0.307
		Recessive	TT-TG	465	447	1
			GG	70	91	0.74 (0.53–1.04)	0.080
		Log-additive				0.86 (0.73–1.03)	0.103
IL-1RN	rs3181052	Genotype	AA	196	185	1
			AG	259	253	0.97 (0.74–1.26)	0.799
			GG	80	100	0.76 (0.53–1.08)	0.123
		Dominant	AA	196	185	1
			AG-GG	339	353	0.91 (0.71–1.16)	0.441
		Recessive	AA-AG	455	438	1
			GG	80	100	0.77 (0.56–1.06)	0.113
		Log-additive				0.89 (0.75–1.05)	0.169
IL-1RN	rs452204	Genotype	AA	237	226	1
			AG	243	240	0.97 (0.75–1.25)	0.793
			GG	52	70	0.71 (0.47–1.06)	0.093
		Dominant	AA	237	226	1
			AG-GG	295	310	0.91 (0.71–1.16)	0.433
		Recessive	AA-AG	480	466	1
			GG	52	70	0.72 (0.49–1.06)	0.092
		Log-additive				0.88 (0.74–1.05)	0.166

SNP single nucleotide polymorphism, OR odds ratio, 95% CI 95% confidence interval
p values were calculated by logistic regression analysis with adjustments for age and gender
*p < 0.05 respects the data is statistically significant

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