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Table 6 Survival analysis for 12 significantly up-regulated hub genes in TCGA-LIHC

From: Three novel circRNAs upregulated in tissue and plasma from hepatocellular carcinoma patients and their regulatory network

Hubgenes

DFI

DSS

PFI

HR(95 %CI)

Log-rank P value

HR(95 %CI)

Log-rank P value

HR(95 %CI)

Log-rank P value

MCM6

1.923(1.358–2.724)

< 0.0001****

1.901(1.217–2.971)

0.0040**

1.865(1.386–2.510)

< 0.0001****

CCNB1

1.847(1.323–2.578)

0.0002***

2.189(1.404–3.412)

0.0005***

1.947(1.447–2.619)

< 0.0001****

CDC20

1.614(1.144–2.278)

0.0038**

3.028(1.936–4.736)

< 0.0001****

1.809(1.345–2.434)

< 0.0001****

NDC80

1.497(1.077–2.081)

0.0155*

1.786(1.145–2.786)

0.0098**

1.501(1.118–2.015)

0.0061**

ZWINT

2.076(1.466–2.938)

< 0.0001****

2.170(1.390–3.389)

0.0006***

1.899(1.377–2.499)

< 0.0001****

ASPM

1.419(1.022–1.972)

0.0360*

1.794(1.135–2.767)

0.0104*

1.432(1.068–1.920)

0.0158*

CENPU

1.497(1.077–2.081)

0.0155*

1.786(1.145–2.786)

0.0098**

1.501(1.118–2.015)

0.0061**

MCM3

1.615(1.160–2.248)

0.0039**

1.734(1.109–2.711)

0.0131*

1.627(1.210–2.186)

0.0010**

MCM5

1.372(0.986–1.908)

0.0576

1.623(1.040–2.532)

0.0305*

1.446(1.076–1.942)

0.0128*

ECT2

1.488(1.070–2.070)

0.0168*

2.084(1.338–3.245)

0.0013**

1.564(1.166–2.098)

0.0026**

CDC7

1.255(0.902–1.745)

0.1726

2.151(1.376–3.364)

0.0006***

1.453(1.073–1.967)

0.0128*

DLGAP5

1.484(1.067–2.064)

0.0177*

2.262(1.452–3.525)

0.0004***

1.671(1.245–2.243)

0.0005***

  1. HR hazard ratio, DFI disease-free interval, DSS disease specific survival, PFI progression free interval