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Fig. 2 | Cancer Cell International

Fig. 2

From: IRF4 overexpression promotes the transdifferentiation of tregs into macrophage‐like cells to inhibit the development of colon cancer

Fig. 2

IRF4 overexpression attenuated colon cancer damage. SW480 cells were transfected with LV-IRF4, LV-ctrl, LV-sh-IRF4 or LV-shRNA. Normal SW480 cells served as control. QRT-PCR (a) and WB (b) were performed to assess the gene and protein expression of IRF4 in the modified SW480 cells. BALB/c mice were injected with normal or the modified SW480 cells. c The expression of IRF4 in the tumors of mice was measured by qRT-PCR. The colon tissues form normal BALB/c mice served as control. d HE staining was performed to explore the pathological changes of tumors. ($$P < 0.01, versus Normal; *P < 0.05, **P < 0.01, versus LV-ctrl; #P < 0.05, ##P < 0.01, versus LV-shRNA)

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Cancer Cell International

ISSN: 1475-2867

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