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Fig. 2 | Cancer Cell International

Fig. 2

From: Disclosing a metabolic signature of cisplatin resistance in MDA-MB-231 triple-negative breast cancer cells by NMR metabolomics

Fig. 2

Average 500 MHz 1H NMR spectra of aqueous extracts from triple-negative breast cancer cells. a sensitive (S), MDA-MB-231, and b resistant (R), MDA-MB-231/R to cDDP, at the beginning of the experiment (t = 0 h). * Cut-off of water suppression region (δ 4.4–5.4), not considered in the multivariate analysis. The arrows identify metabolic variations found with visual inspection of spectra of R cells in relation to S cells. 3-letter code for amino acids; ADP adenosine diphosphate, AMP adenosine monophosphate, ATP adenosine triphosphate, BCAAs branched-chain amino acids (Ile, Leu and Val), Cho choline, Cr creatine, GPC glycerophosphocholine, GSH glutathione (reduced), GTP guanosine triphosphate, HX hypoxanthine, m-Ino myo-Inositol, Lac lactate, NAD+ nicotinamide adenine dinucleotide (oxidized), PC phosphocholine, Pseudourd. Pseudouridine, Tau taurine, UDP-Glc/GlcA uridine diphosphate-glucose/glucuronate, UDP-GlcNAc uridine diphosphate N-acetyl-glucosamine

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Cancer Cell International

ISSN: 1475-2867

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