Fig. 7

Putative metabolic pathways explaining the differences between polar metabolomes of MDA-MB-231/R and MDA-MB-231 cell lines. Metabolites in bold represent those identified by NMR. Changes in metabolite levels are illustrated as color bars according to the effect size variations for the R vs. S cells pairwise comparison (blue and red represent decreases and increases, respectively). Anaplerotic amino acids classified as ketogenic or glucogenic are indicated with ^a(within rectangles with cut vertexes) or ^b(within rectangles with straight vertexes), respectively. Possible relationships with the ERK(/MAPK) signaling pathway are indicated in grey ellipses. Metabolic pathways are distinguished by different colors, namely creatine metabolism in cyan, amino acids metabolism in green, glycerophospholipids (GPL) metabolism in orange, energy metabolism in blue, antioxidant metabolism in purple, nucleotide sugars metabolism & pentose-glcA interconversions in yellow, and pyrimidine & purines metabolism in red. F6P fructose 6-phosphate, G1P glucose 1-phosphate, G6P glucose 6-phosphate, GA guanidine acetate, GlcA1P glucuronate 1-phosphate, GlcA glucuronate, GlcN-6P glucosamine 6-phosphate, PPP pentose phosphate pathway, PRPP phosphoribosyl pyrophosphate, Urd uridine, UTP uridine