Fig. 5

Downregulation of DPY30 suppresses CRC tumor metastasis in vivo. A Representative gross images of lung metastatic nodules in nude mice that received intravenously tail vein injection of HT29 and SW480 cells with stable DPY30 knockdown (HT29-shDPY30 and SW480-shDPY30) or control vector at 10 weeks. B Number of metastatic tumor nodules in the lung of mice. Data are presented as mean ± SD; n = 7 for each group. **P < 0.01, ***P < 0.001. C Representative images of lung tissues from mice after fixing with 10% paraformaldehyde. D Representative images of hematoxylin and eosin-stained histological sections of lungs from nude mice with/without metastasis illustrating local invasiveness. (Left, HT29 model; right, SW480 model). E Representative images of transverse (upper) and coronal (bottom) sections of CT images and PET-CT images of nude mice compared with corresponding controls