Table 1 Current licensed human papillomavirus vaccines
Brand Name | Gardasil | Cervarix | Gardasil 9 | Cecoline |
|---|---|---|---|---|
Manufacturer | Merck & Co | GlaxoSmithKline | Merck & Co | Xiamen Innovax |
Valency | quadrivalent | bivalent | nonavalent | bivalent |
VLP Types | HPV6/11/16/18 | HPV16/18 | HPV6/11/16/18/31/33/45/52/58 | HPV16/18 |
First Licensed | 2006 | 2007 | 2014 | 2021 |
Doses Recommended | 2 or 3 doses, depending on age at initiation | 2 or 3 doses, depending on age at initiation | 2 or 3 doses, depending on age at initiation | 2 or 3 doses, depending on age at initiation |
Administration | Intramuscular | Intramuscular | Intramuscular | Intramuscular |
Expression System | Saccharomyces cerevisiae (Baker’s yeast) | Trichoplusia ni Rix4446 cell using the baculovirus expression vector | Saccharomyces cerevisiae (Baker’s yeast) | Escherichia coli |