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Table 2 Current approaches to cervical cancer screening. WHO recommends using HPV DNA detection as the primary screening test among the general population of women, and using partial genotyping, colposcopy, visual inspection with acetic acid or cytology to triage women after a positive HPV DNA. HPV mRNA is an alternative method to HPV DNA tests for HPV detection

From: Clinical applications and utility of ctDNA in cervical cancer and its precursor lesions: from screening to predictive biomarker

Molecular tests

Cytology tests

Visual inspection

HR-HPV DNA

Pap smear

Visual inspection with acetic acid or with Lugol’s iodine mainly by the colposcope

HR-HPV mRNA

Liquid-based cytology (LBC)

 

Dual staining to identify p16 and Ki-67