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Fig. 6 | Cancer Cell International

Fig. 6

From: Loss of two-pore channel 2 function in melanoma-derived tumours reduces tumour growth in vivo but greatly increases tumour-related toxicity in the organism

Fig. 6

Cytokines, chemokines, and angiogenesis markers in the liver, spleen, and serum 5 weeks after injecting mice with CHL-1 WT or TPC2 KO melanoma cells. (A) Heatmap representing the overall number of differentially expressed markers in the spleen and liver tissues and serum after injection with CHL-1 WT or TPC2 KO cells. Data in heatmap represents the mean ± s.e.m. of three independent experiments. (B) qPCR validation of representative markers in spleen and liver tissues. Data in bar charts represent the mean ± s.e.m. of three independent experiments (* p < 0.05; ** p < 0.01; *** p < 0.001)

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Cancer Cell International

ISSN: 1475-2867

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