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Fig. 5 | Cancer Cell International

Fig. 5

From: Tumour cells can escape antiproliferative pressure by interferon-β through immunoediting of interferon receptor expression

Fig. 5

STAT1/2 phosphorylation upon stimulation with 130 IU/ml IFN-β. a Representative immunoblots of HLE, HLF, PLC and the non-malignant PH5CH control. Samples were adjusted for total protein content; calnexin levels vary between cell lines. Illustration on the right shows an overview of the IFN signalling pathway indicating all molecules assessed in the figure. b + c Quantified levels of phosphorylated STAT (pSTAT) relative to corresponding mean total STAT. Area under curve (AUC) used to quantify response over full time course. d + e Same data as in b + c, pSTAT normalised to its peak values (100%) to allow for better comparison of kinetics. All graphs display mean ± SD of three independent repetitions. Statistical analysis was performed with one-way ANOVA followed by Tukey’s multiple comparison test

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Cancer Cell International

ISSN: 1475-2867

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