Table 1 Therapeutic effects of active ingredients in green tea on cervical cancer

Epigallocatechin gallate (EGCG) and polyphenols E

0–50 µg/ml

HPV-E7

Inhibited immortalized cervical epithelial and cancer cell growth, apoptosis is induced by EGCG in a dose-dependent statistically

In-vitro

TCL1, HeLa, Me180

[27]

EGCG

250–500 µM

-

Induced cell cycle arrest and apoptosis, Inhibited cell Growth

In-vitro

HeLa, C33A, WI-38

[28]

EGCG

25 µM

NFκB p65, COX-2, p-Akt, p-mTOR

Inhibited growth of cervical cancer cells, inhibited cell survival and induced apoptosis

In-vitro

HeLa

[29]

Sinecatechins

160 to 360µM

-

Inhibited cancer cell growth, induced apoptosis, mediated by cell cycle deregulation

In-vitro

CaSki, SiHa, HeLa, C4-I

[30]

Green tea

-

-

A protective factor against cervical cancer

Human

-

[31]

Polyphenon E

800 mg

CIN1

Did not promote the clearance of persistent high-risk HPV and related CIN1

Human

-

[32]

EGCG

60 µg/mL

-

Cytostatic but not cytotoxic effect

In-vitro

HeLa

[33]

EGCG

1-100 µM

MMP-9, TIMP-1

Induced apoptosis and inhibited invasion and migration

In-vitro

HeLa

[34]

epigallocatechin-3-gallate

50 µg/ml

SOD, GPx

Free radical scavenging properties, protected the proliferation of cancerous cells and boosted the activity of SOD and GPx

In-vitro, human

HeLa

[35]

EGCG

35 µM

-

Inhibited cervical cancer cell growth through induction of apoptosis and cell cycle arrest

In-vitro

CaSki

[36]

EGCG

0, 25, 50 µM

-

Inhibited proliferation, induced cell cycle arrest

In-vitro

HeLa

[37]

EGCG

25 µM

DNMT3B

Reversed expression of various tumor-suppressor genes by inhibiting DNA methyltransferases and histone deacetylases

In-vitro

HeLa

[38]

EGCG

25 or 50 µM

p53

Suppressed Fused Toes Homolog protein

In-vitro

HeLa

[39]

EGCG

25–100 µg/ml

cyclinD1, LIMD1, RBSP3, p16, DNMT1

Inhibited cellular proliferation, Induced apoptosis

In-vitro

HeLa

[40]

Catechin hydrate (CH)

50–600 lg/mL

tp53, caspase-3, -8, -9

Inhibited proliferation and mediated apoptosis

In-vitro

SiHa

[41]

Tea extract and EGCG

0-100 µM /L

TGF-β

Suppressed TGF-β-induced EMT, decreased ROS levels

In-vitro

Hela, SiHa

[42]

EGCG

50–100 µM

DNMT, HDAC, HMT, H3K9

Decreased global DNA methylation

In-vitro

HeLa

[43]

EGCG

10 µM

-

Affected proliferation, adhesion and motility

In-vitro

HeLa

[44]

EGCG, tea polyphenol

0–100 mM

IGF-IR

Inhibited the proliferation, induced cell apoptosis

In-vitro

OMC-4, TMCC-1

[45]

EGCG

0-100 µg/ml

miR-203, miR-125b

Inhibited cell proliferation

In-vitro

HeLa, CaSki, C33A

[46]

EGCG

0-100 µM

-

Antiproliferative effects

In-vitro

HeLa and TMCC-1

[47]

EGCG

25, 50 µM

-

Inhibited Cell growth and poliferation

In-vitro

CaSki, HeLa

[48]

EGCG

5, 10 µg/ml

caspase-3

Increased number of apoptotic cells

In-vitro

PBMCs

[49]

Green tea extract, EGCG

80 µg/mL, 100 µmol/L

VEGF

Abolished cell migration

In-vitro

HeLa, HepG2

[50]