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Fig. 5 | Cancer Cell International

Fig. 5

From: CD56 polysialylation promotes the tumorigenesis and progression via the Hedgehog and Wnt/β-catenin signaling pathways in clear cell renal cell carcinoma

Fig. 5

PSA-CD56 promoted proliferation, invasion and migration of ccRCC cells in vitro. A The proliferation ability of Caki-1 cells with stably overexpression-CD56 and CD56-N459,488Q was determined by CCK-8 assay. B The colony formation ability of cells was evaluated by colony formation assay. C The migration ability of overexpression of CD56 and CD56-N459,488Q in Caki-1 cells by cell scratch assay within 36 h. D Transwell assays for the effects of overexpression CD56 and CD56-N459,488Q on migration and invasion ability of Caki-1 cells. E Representative images of the protein of Hedgehog and Wnt/β-catenin signaling pathways in Caki-1 cells with stably overexpression-CD56 and CD56-N459,488Q measured by western blot. Results were expressed as the mean ± SD of three independent experiments. Scale bars: 400 μm. **P < 0.01, ***P < 0.001, ****P < 0.0001, N.S. represents no statistical significance by two-way ANOVA (A), or one-way ANOVA (B, C, D, E)

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Cancer Cell International

ISSN: 1475-2867

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