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Fig. 2 | Cancer Cell International

Fig. 2

From: Single-cell histone chaperones patterns guide intercellular communication of tumor microenvironment that contribute to breast cancer metastases

Fig. 2

HCs modified the features of CAFs. (A) Trajectory analysis revealed the role of HCs in CAFs. (B) Cell–Cell communications from HCs-mediated CAFs to malignant cells. (C) Bar plot for 4 HCs-mediated CAFs clusters between brain metastasis and liver metastasis patients. (D) Heatmap showing the activated KEGG pathways in HCs‑mediated CAFs. (E) Different HCs-mediated CAFs clusters were correlated with the previous signatures. (F) Heatmap showing the significantly different TFs among HCs-mediated CAFs. (G) Heatmap showing the different average expression of common signaling pathway genes in the HCs-mediated CAFs, including collagens, ECM, MMPs, TGFβ, Neo-Angio, Contractile, RAS and Proinflammatory

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Cancer Cell International

ISSN: 1475-2867

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