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Fig. 4 | Cancer Cell International

Fig. 4

From: Single-cell histone chaperones patterns guide intercellular communication of tumor microenvironment that contribute to breast cancer metastases

Fig. 4

NMF clusters of HCs for T/NK cells. (A) t-SNE plot of T/NK cells by six cell types, including CD4 + T cells, CD8 + T cells, Tregs, NK cells, NKT cells, and other T cells. (B) Cell–Cell communications from main HCs-mediated T/NK cells to other cells by Cellchat analysis. (C) Bar plot of main HCs-mediated T/NK cells clusters between brain metastasis and liver metastasis patients. (D) Heatmap showing significantly different TFs among HCs-mediated clusters in CD4 + T cells, CD8 + T cells, NK cells, and Tregs. (E, F) Heatmap showing significantly different features among T clusters in CD4 + T cells, CD8 + T cells, NK cells, and Tregs, including immune stimulators, inhibitors and T cell function marker genes, as well as four T function signatures (T exhaustion score, T cytotoxic score, T effector score, and T evasion score)

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Cancer Cell International

ISSN: 1475-2867

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