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Fig. 3 | Cancer Cell International

Fig. 3

From: The 4-1BBζ costimulatory domain in chimeric antigen receptors enhances CD8+ T-cell functionality following T-cell receptor stimulation

Fig. 3

CD8+ 4-1BBζ CAR T-cells exhibit increased proliferation after stimulation with SEB. A, B Representative flow cytometry histograms of proliferation of A CD4+, and B CD8+ cell products labelled with CellTrace Violet and stimulated with staphylococcal enterotoxin B for 5 days. The grey histogram indicates the unstimulated control. C, D Bar graphs of the percentage of divided C CD4+, and D CD8+ cell products. E, F Bar graphs of the division index (the average number of divisions) in E CD4+, and F CD8+ cell products. Experiments were performed on different days for three independent donors; each donor is distinguished using a unique symbol. Data represents mean ± SEM. Comparisons were made between all cell products by one-way ANOVA with Tukey’s correction for multiple comparisons; only statistically significant differences are indicated (*p < 0.05, **p < 0.01)

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Cancer Cell International

ISSN: 1475-2867

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