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Fig. 1 | Cancer Cell International

Fig. 1

From: LncRNA AGAP2 antisense RNA 1 stabilized by insulin-like growth factor 2 mRNA binding protein 3 promotes macrophage M2 polarization in clear cell renal cell carcinoma through regulation of the microRNA-9-5p/THBS2/PI3K-Akt pathway

Fig. 1

IGF2BP3 affects the expression of AGAP2-AS1 in RCC through m6A modification. A Volcano maps of normal kidney tissue and RCC samples in the GSE36895 dataset. Red dots refer to upregulated genes, green dots refer to downregulated genes, and black dots refer to genes without significant differential expression. B Venn diagram of differentially expressed genes and m6A regulators. C Expression of IGF2BP3 in RCC. D Heat map of correlation between IGF2BP3 and differentially expressed lncRNAs in the GSE36895 dataset. Red indicates a positive correlation, and blue indicates a negative correlation. E Venn map of the overlap of AGAP2-AS1 and LINC01094, which are positively related to IGF2BP3, with IGF2BP3 substrates in m6a2target database. F Correlation between IGF2BP3 and AGAP2-AS1 expression. G The levels of AGAP2-AS1 and IGF2BP3 in clinical samples. H Expression of AGAP2-AS1 in ccRCC cells. I meRIP detected the modification of m6A on AGAP2-AS1. J AGAP2-AS1 expression in cells; K, L Half-life of AGAP2-AS1 after actinomycin D treatment and IGF2BP3 overexpression. M AGAP2-AS1 enrichment in cells tested by RIP. N Schematic diagram of the binding sites of AGAP2-AS1 and IGF2BP3. O, P Luciferase activity in different treatment groups. * p < 0.05 vs. Compared with Normal group, HK-2 group, IgG group or Vector group

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Cancer Cell International

ISSN: 1475-2867

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