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Fig. 4 | Cancer Cell International

Fig. 4

From: LncRNA AGAP2 antisense RNA 1 stabilized by insulin-like growth factor 2 mRNA binding protein 3 promotes macrophage M2 polarization in clear cell renal cell carcinoma through regulation of the microRNA-9-5p/THBS2/PI3K-Akt pathway

Fig. 4

THBS2 activates the PI3K/Akt signaling pathway to induce M2 polarization of macrophages. A, B Transfection efficiency of sh-THBS2 detected by RT-qPCR. C, D Cell viability test by CCK-8. E, F Expression of PI3K/AKT signaling pathway proteins after co-culture of sh-THBS2-/oe-THBS2-treated cells with macrophages. G, H Expression of M1 polarization and M2 polarization markers in macrophages. I, J Expression of PI3K/AKT signaling pathway proteins. K, L Macrophage M1 and M2 polarization marker expression. * p < 0.05 vs. sh-NC group, sh-NC + M group or oe-THBS2 + DMSO + M group. # p < 0.05 vs. oe-NC group or oe-NC + M group

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Cancer Cell International

ISSN: 1475-2867

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