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Fig. 6 | Cancer Cell International

Fig. 6

From: LncRNA AGAP2 antisense RNA 1 stabilized by insulin-like growth factor 2 mRNA binding protein 3 promotes macrophage M2 polarization in clear cell renal cell carcinoma through regulation of the microRNA-9-5p/THBS2/PI3K-Akt pathway

Fig. 6

AGAP2-AS1/miR-9-5p/THBS2 axis induces M2 polarization of macrophages and aggravates RCC in vivo. A Tumor volume following sh-AGAP2-AS1 and oe-THBS2 treatment. B Tumor weight following sh-AGAP2-AS1 and oe-THBS2 treatment. C AGAP2-AS1, miR-9-5p and THBS2 expression in tumors of each group following sh-AGAP2-AS1 and oe-THBS2 treatment. D Ki67 expression level in tumor sections assessed by immunohistochemistry. E PI3K/AKT signaling pathway-related protein expression in tumors following sh-AGAP2-AS1 and oe-THBS2 treatment. F Macrophage M1 and M2 polarization marker expression levels tested by RT-qPCR. G Representative HE staining images of lung tissues of nude mice in each group and quantitative analysis of metastatic nodes in lung sections. * p < 0.05 vs. sh-NC + oe-NC group; # p < 0.05 vs. sh-AGAP2-AS1 + oe-NC group

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Cancer Cell International

ISSN: 1475-2867

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