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Fig. 6 | Cancer Cell International

Fig. 6

From: A RBM47 and IGF2BP1 mediated circular FNDC3B-FNDC3B mRNA imbalance is involved in the malignant processes of osteosarcoma

Fig. 6

CircFNDC3B also reduced FNDC3B mRNA stability by competitively binding to IGF2BP1. A Subcellular localization of circFNDC3B displayed by RNA FISH; scale bar represents 5 μm. B Subcellular localization of IGF2BP1 protein displayed by immunofluorescence; scale bar represents 5 μm. C Interaction of IGF2BP1 with circFNDC3B and FNDC3B mRNA validated by RIP assays. D, E Regulation of IGF2BP1 on circFNDC3B and FNDC3B mRNA expression evaluated by qRT-PCR. F, G Influence of IGF2BP1 on circFNDC3B and FNDC3B mRNA stability. H, I Regulation of circFNDC3B on FNDC3B mRNA expression evaluated by qRT-PCR. J Influence of circFNDC3B on FNDC3B mRNA stability. K,L The influence of circFNDC3B overexpression or silence on the interaction of IGF2BP1 with FNDC3B mRNA was validated by RIP assays. Data were shown as the mean ± SD, *P < 0.05, **P < 0.01, ***P < 0.001

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Cancer Cell International

ISSN: 1475-2867

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