A RBM47 and IGF2BP1 mediated circular FNDC3B-FNDC3B mRNA imbalance is involved in the malignant processes of osteosarcoma

Table 1 Correlation between the clinical variables of OS patients with circFNDC3B or FNDC3B mRNA expression

Clinical variables	N	circFNDC3B		P	FNDC3B mRNA		P
Clinical variables	N	Low	High	P	Low	High	P
Gender
Male	28	13	15		15	13
Female	22	12	10	0.388	10	12	0.388
Age
< 25y	33	14	19		17	16
≥ 25y	17	11	6	0.116	8	9	0.500
Tumor size
< 6 cm	29	10	19		22	7
≥ 6 cm	21	15	6	0.010	3	18	0.000
Lymph node metastasis
No	34	13	21		20	14
Yes	16	12	4	0.016	5	11	0.064
Enneking stage
I + IIA	35	14	21		20	15
IB + III	15	11	4	0.031	5	10	0.108
Differentiation
Well/moderately	31	15	16		16	15
Poorly/undifferentiated	19	10	9	0.500	9	10	0.500
Location
Femur/tibia	34	17	17		16	18
Elsewhere	16	8	8	0.619	9	7	0.381

ISSN: 1475-2867