Table 2 Role of ESRP1 in cancer progression
From: Role of epithelial splicing regulatory protein 1 in cancer progression
No | Cancer type | Roles | Functions | References |
|---|---|---|---|---|
1 | Bladder cancer | Tumor suppressive | ESRP1 decreases cell growth and migration (in vitro) ESRP1 inhibits xenograft tumor formation and reduces the occurrence of lung metastasis (in vivo) | [18] |
2 | Cervical cancer | Tumor suppressive | ESRP1 induces cell cycle G1-phase arrest and inhibits cell proliferation (in vitro) | [53] |
3 | Colorectal cancer | Tumor suppressive | ESRP1 inhibits anchorage-independent growth (in vitro) ESRP1 suppresses tumorigenic potential (in vivo) | [15] |
4 | Colorectal cancer | Tumor promoting | ESRP1 promotes proliferation and tumorigenicity (in vitro) ESRP1 enhances primary tumor growth (in vivo) | [49] |
5 | Colorectal cancer | Tumor promoting | ESRP1 knockdown promotes caspase-independent cell death (in vitro) | [50] |
6 | Gastric cancer | Tumor suppressive | ESRP1 decreases migration and invasion (in vitro) | [54] |
7 | Head and neck cancer | Tumor suppressive | ESRP1 decreases cell motility (in vitro) | [51] |
8 | Lung cancer (lung adenocarcinoma) | Tumor suppressive | ESRP1 knockdown enhances invasion (in vitro) ESRP1 knockdown suppresses tumor growth and liver metastasis (in vivo) | [17] |
9 | Lung cancer (small-cell lung cancer) | Tumor suppressive | ESRP1 induces cell apoptosis and cell cycle arrest (in vitro) ESRP1 inhibits tumor growth (in vivo) | [46] |
10 | Pancreatic cancer | Tumor suppressive | ESRP1 decreases migration and invasion (in vitro) ESRP1 attenuates liver metastases (in vivo) | [16] |
11 | Prostate cancer | Tumor suppressive | ESRP1 inhibits tumor growth (in vivo) | [61] |
12 | Breast cancer | Tumor promoting | ESRP1 promotes lung metastasis (in vivo) | [19] |
13 | Breast cancer | Tumor promoting | ESRP1 promotes lung metastasis (in vivo) | [20] |
14 | Breast cancer (ER-positive breast cancer) | Tumor promoting | ESRP1 knockdown inhibits cell growth (in vitro and in vivo) | [21] |
15 | Breast cancer | Tumor suppressive | ESRP1 knockdown increases invasion (in vitro) | [11] |
16 | Breast cancer | Tumor suppressive | ESRP1 decreases tumor cell contractility and intravasation (in vitro and in vivo) | [56] |
17 | Ovarian cancer | Tumor promoting | ESRP1 increases cell proliferation and decreases migration (in vitro) | [13] |
18 | Ovarian cancer | Tumor promoting | ESRP1 inhibits cell migration and invasion but promotes colonization (in vitro) ESRP1 enhances tumor growth (in vivo) | [14] |