Altering phosphorylation in cancer through PP2A modifiers

Johnson, Hannah; Narayan, Satya; Sharma, Arun K.

doi:10.1186/s12935-023-03193-1

Cancer Cell International

Table 2 Indirect PP2A activators

From: Altering phosphorylation in cancer through PP2A modifiers

Compounds	Cancer Types	Mechanisms	References
FTY720	Acute myeloid leukemia	Impairs interaction of PP2Ac with SET	[81]
	Neuroblastoma	Inhibits proliferation, migration, and invasion	[68, 136]
	Chronic myeloid leukemia	Impairs interaction of SET-PP2A, inhibits the BCR-ABL1 recruitment of JAK2, and activates GSK-3β	[137]
	Colorectal cancer	Decreased phosphorylation of AKT1 and Erk1/2	[79]
	Breast cancer	Increases activation and expression of ERα and inhibits histone deacetylase	[23, 138]
	Oral squamous cell carcinoma	Decreased phosphorylated GSK-3β	[25]
	Multiple myeloma	Ferroptosis, autophagy, apoptosis, and ROS activation	[84, 85]
	Ovarian cancer	Autophagy and non-apoptotic cell death	[88]
	Gastric cancer	Increases PTEN and p53, decreases p-AKT1 and MDM2, induces G1 cell cycle arrest and apoptosis	[87]
	Lung cancer	Decreases S1P-induced IL-6 and IL-8 and TNF-induced COX2, activation of PP2A-RIPK1-dependent necroptosis	[82, 86]
	Hepatocellular carcinoma	ROS-dependent activation of PKCδ and caspase-3-dependent apoptosis	[139]
CM-1231	Acute myeloid leukemia	Targets SET	[91]
OSU-2S	Acute myeloid leukemia	Impairs interaction of SET and PP2Ac, c-Myc degradation and increased p21	[90]
OSU-2S	Chronic lymphocytic leukemia	Nuclear translocation of SHP1^S591	[89]
OP449	Acute myeloid leukemia	Antagonizes SET	[81, 140]
OP449	Chronic myeloid leukemia	Antagonizes SET	[140]
Bortezomib	Triple negative breast cancer	Inhibits CIP2A, decreased p-AKT1	[78, 79]
Bortezomib	Colorectal cancer
Ethoxysanguinarine (ESG)	Lung cancer	Inhibits CIP2A, decreased c-Myc and p-AKT1, apoptosis	[94]
TD52	Triple negative breast cancer	Inhibits CIP2A, interrupts ELK1 binding to CIP2A promoter, decreased p-AKT1	[93]
TD52	Hepatocellular carcinoma		[95]
Arctigenin	Triple negative breast cancer	Inhibits CIP2A	[141]
Celastrol	Gastric cancer	CIP2A degradation, increased apoptosis	[142]
Niclosamide	Non-small cell lung cancer	Inhibits CIP2A, increased mitochondrial ROS	[143]
Polyphyllin I	Prostate cancer	Inhibits CIP2A and ERK	[99]
Lapatinib	Triple negative breast cancer	Inhibits CIP2A and p-AKT1	[98]

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ISSN: 1475-2867

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