Table 3 PP2A inhibitors

LB-100

Medulloblastoma

Decreased activation of STAT3 (↑Ser727-p-STAT3)

[144]

Glioblastoma

Activates Plk-1 and AKT-1, inhibits p53

[118]

Pancreatic cancer

Activates CDC25C/CDK1, inhibits homologous recombination repair (HRR)

[120]

Cantharidin

Pancreatic Cancer

G2/M cell cycle arrest, decreased CDK1, and increased p21

[107]

Hepatocellular carcinoma

Binds to EphB4, regulating JAK2/STAT3 pathway

[145]

Noncantharidin

Colorectal cancer

Activates the CD95 receptor/ligand

[146]

Okadaic Acid

Lung cancer

Induces apoptosis

[114, 115]

Calyculin A

Breast cancer

Increases p-Cyclin D1 and initiates its degradation

[147]

Tautomycin

Medullary thyroid cancer

Inhibition of GSK-3β

[148]

Tautomycetin

Medullary thyroid cancer

Inhibition of GSK-3β

[148]

Fostriecin

Leukemia

Binds to Cys269 residue of PP2Ac

[149]

Small-cell lung carcinoma

Inhibits TopoII without forming a complex with DNA and TopoII

[111]

Ovarian cancer

Activates STAT1

[112]