Role of long non-coding RNAs in metabolic reprogramming of gastrointestinal cancer cells

Wang, Kang; Lu, Yan; Li, Haibin; Zhang, Jun; Ju, Yongle; Ouyang, Manzhao

doi:10.1186/s12935-023-03194-0

Cancer Cell International

Table 1 LncRNAs involved in the regulation of glucose metabolism of gastrointestinal cancer cells

From: Role of long non-coding RNAs in metabolic reprogramming of gastrointestinal cancer cells

Tumor type	LncRNA	Expression	Metabolism-related enzyme	Metabolic process	Clinical prognosis	Ref
Colon cancer	LINC00504	Up	LDHA, HK2, GADPH	Glucose uptake, glycolysis, pentose phosphate pathway	–	[39]
	GLCC1	Up	LDHA	Glycolysis	Poor	[40]
	LINRIS	Up	GLUT-1, PKM2, LDHA	Glycolysis, glucose uptake	Poor	[41]
	HOXB-AS3	Down	PKM2	Glycolysis	Poor	[42]
	FEZF1-AS1	Up	PKM2	Glycolysis	Poor	[43]
	MAFG-AS1	Up	PDK1, PFK1, PKM2	Glycolysis, Krebs cycle	Poor	[44]
	HNF1A-AS1	Up	HK2	Glycolysis	Poor	[45]
	CRNDE	Up	GLUT, PDK4	Glucose uptake, glycolysis	–	[46]
	LINC00265	Up	GLUT, PKM, LDH	Glucose uptake, glycolysis	Poor	[47]
	LincRNA-p21	Down	PDK, PDH	Glucose uptake, glycolysis	–	[48]
	MALAT1	Up	GLUT1, HK2, PKM2, LDH	Glycolysis, glucose uptake	–	[49]
	AWPPH	Up	GLUT1	Glucose uptake	–	[50]
	HCG11	Up	PDK4	Glycolysis	Poor	[51]
Gastric cancer	MACC1-AS1	Up	HK2, GLUT1, LDHA, G6PD	Glycolysis, glucose uptake, pentose phosphate pathway	Poor	[52]
	Ftx	Up	HK2	Glycolysis	–	[53]
	DLX6-AS1	Up	PDK1	Glycolysis	Poor	[54]
	IGF2-AS	Up	HK2	Glycolysis, glucose consumption, and lactate production	Poor	[55]
	MSC-AS1	Up	PFKFB3	Glycolysis	Poor	[56]
	LINC00242	Up	G6PD	Glycolysis	Poor	[57]
	SNHG1	Up	HK2	Glycolysis	Poor	[58]
	DLEU2	Up	LDHA	Glycolysis	Poor	[59]
Liver cancer	Ftx	Up	PDK1, GLUT1, GLUT4, PFK, LDH	Glycolysis, glucose uptake	Poor	[60]
	MEG3	Down	PKM2	Glycolysis	Poor	[61]
	CUDR	Up	PKM2	Glycolysis	–	[62]
	LINC01554	Down	PKM2	Glycolysis	Poor	[63]
	H19	Up	PKM2	Glycolysis	–	[64]
	WFDC21P	Down	PFK, PKM2	Glycolysis	Poor	[65]
	RAET1K	Up	LDHA	Glucose uptake	Poor	[66]
	MALAT1	Up	HK2, GLUT4	Glycolysis, glucose uptake	–	[67]
	SOX2OT	Up	PKM2	Glucose uptake, glycolysis lactate production	Poor	[68]
	SLC2A1-AS1	Down	GLUT1	Glycolysis	Poor	[69]
	LOXL1‑AS1	Up	GLUT	Glucose uptake	Poor	[70]
	FTO- IT1	Up	GLUT1, PKM2	Glucose uptake, glycolysis	Poor	[71]
Esophageal cancer	NBAT-1	Down	PKM2	Glycolysis	Poor	[72]
	HOTAIR	Up	HK2	Glycolysis	Poor	[73]
	AGPG	Up	PFKFB3	Glycolysis	Poor	[74]
	LINC00184	Up	HK, LDHA, PDH	Glycolysis	–	[75]
	SLC2A1-AS1	Up	GLUT1	Glycolysis, glucose uptake	Poor	[76]
	G077640	Up	GLUT4, HK2, PDK1	Glycolysis, glucose uptake	Poor	[77]
Pancreatic cancer	MACC1-AS1	Up	PK	Glycolysis	Poor	[78]
	HOTAIR	Up	HK2	Glycolysis, glucose uptake	Poor	[79]
	LINC01448	UP	HK2	Glucose consumption, lactate production	Poor	[80]
	PVT1	Up	HK2, GLUT1, LDHA	Glycolysis, glucose uptake	Poor	[81]
	DICER1-AS1	Down	HK2, LDHA	Glycolysis	Poor	[82]
Gallbladder cancer	PVT1	Up	HK2	Glycolysis	Poor	[83]

GLUT Glucose transporter, HK Hexokinase, PK Pyruvate kinase, LDH Lactate dehydrogenase, PDK Pyruvate dehydrogenase kinase, PFK Phosphofructokinase, PKM2 Pyruvate kinase type M2, LDHA Lactate dehydrogenase A, GADPH Glyceraldehyde-3-phosphate dehydrogenase, G6PD Glucose-6-phosphate dehydrogenase, PFKFB3 6-phosphate fructose-2-kinase, PDH pyruvate dehydrogenase

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ISSN: 1475-2867

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