Role of long non-coding RNAs in metabolic reprogramming of gastrointestinal cancer cells

Table 2 LncRNAs involved in the regulation of lipid metabolism of gastrointestinal cancer cells

Tumor type	LncRNA	Expression	Metabolism-related enzyme	Metabolic process	Clinical prognosis	Ref
Colorectal cancer	LINC00504	Up	FASN	Lipid synthesis	–	[39]
	CRNDE	Up	FASN	Lipid synthesis	–	[46]
	SNHG16	Up	SCD	Lipid synthesis	–	[91]
Liver cancer	HULC	Up	ACSL1	Lipid synthesis	–	[92]
	NEAT1	Up	ATGL	Lipid synthesis	Poor	[93]
	RP11-386G11.10	Up	FASN, ACC, SCD	Lipid synthesis, lipolysis	Poor	[94]
Cholangiocarcinoma	HAGLROS	Up	FASN, ACC, SCD1	Lipid synthesis, lipolysis	Poor	[95]
Gastric cancer	MACC1-AS1	Up	CPT, ACS	Lipolysis	Poor	[97]
	PEP-AKR1C2	Up	CPT	Lipolysis	Poor	[98]
Pancreatic cancer	NONHSAT105177	Down	HMGCR	Lipid synthesis	–	[96]

FASN Fatty acid synthase, ACC Acetyl-CoA carboxylase, ATGL Adipose triglyceride lipase, SCD Stearoyl CoA desaturase, ACS acetyl-CoA synthase, CPT Carnitine palmitoyl transferase, ACSL1 ACS long-chain family member 1, HMGCR Hydroxy methylglutaryl coenzyme CoA reductase

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