Fig. 1

M6A dynamic regulation. Simple model of m6A Dynamic regulation. m6A methylation is regulated by methyltransferase (“Writers”), demethylases (“Erasers”) and m6A-binding proteins (“Readers”). Methyltransferase METTL3/14, WTAP, VIRMA, ZC3H13, RBM15/15B etc. mainly catalyze the modification of mRNA by m6A. Demethylases, including FTO and ALKBH5, are used to demethylate bases modified by m6A. The main function of m6A-binding proteins is to recognize sites modified by m6A, thereby activating downstream regulatory pathways such as RNA degradation and miRNA processing. The m6A site is bound to different readers to accommodate different functions