Fig. 2

primary contributions of m6A methylases in liver cancer. Major roles of m6A methylases(METTL3、METTL14、WTAP) in the occurrence and development of liver cancer. Increased expression of METTL3: A reduces the stability of SOCS2 mRNA through m6A YTHDF2-dependent pathway, thus promoting the occurrence and development of liver cancer; B promotes the modification of ASPM mRNA and promote the proliferation, migration and invasion of hepatoma cells. Moreover, overexpression of miR-186 significantly inhibited the expression of METTL3, thereby affecting the expression of Wnt/β-catenin pathway-related proteins such as β-catenin, thus promoting the proliferation, migration and invasion of hepatoma cells. METTL14 is a tumor suppressor gene, and its decreased expression may promote hepatocarcinogenesis. The up-regulated expression of WTAP in HCC also indicates poor prognosis and poor patient survival