RNA m6A methylation regulators in liver cancer

Table 1 Functions of m6A ‘writers’ in liver cancer

Regulator	Effect on m6A modification	Expression change	(Refs.)
METTL3	Catalytic core of methyltransferase	Up	36, 37
METTL14	Forms a heterodimer with METTL3 without catalytic action, enhancing the activity of METTL3	Down	38–40
WTAP	Anchors the methyltransferase complex in the nuclear speckles	Up	^{36,37,38,39,40}
RBM15/15B	Binding to the U-rich region to recruit m6A complexes	Up	^37,38,41
KIAA1429(VIRMA)	Interacts with WTAP and recruits m6A to the 3’UTR	Up	36,41
METTL16	Catalyzes m6A installation in the 3’UTR in mRNA and on A43 of U6 small nuclear RNA	Up	^41,42
HAKAI	Necessary for the methylation of m6A	Up	⁴²
ZC3H13	Promotes the WTAP localization and m6A deposition	Down	³⁸

m6A, N6-methyladenosine; METTL3, methyltransferase-like protein3; METTL14, methyltransferase
-like protein 14; WTAP, Wilms tumor 1-associated protein; RBM15/15B, RNA binding motif protein 15/15B; KIAA1429 also called VIRMA, vir-like m6A methyltransferase-associated protein; METTL16, methyltransferase-like protein16;HAKAI, Casitas B lineage lymphoma transformation sequence-like protein 1 (CBLL1); ZC3H13, zinc finger CCCH domain-containing protein 13

ISSN: 1475-2867