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Table 2 Functions of m6A ‘erasers’ in liver cancer

From: RNA m6A methylation regulators in liver cancer

Regulator

Effect on m6A modification

Expression change

(Refs.)

FTO

Removes m6A and m6Am modification, regulates pre-mRNA alternative splicing

Up/down

[45, 46]

ALKBH5

Removes m6A modification, regulate mRNA processing, metabolism and export

Up/down

[49, 50]

  1. m6A, N6-methyladenosine; FTO, fat mass and obesity-associated protein; ALKBH5, AlkB homolog 5
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Cancer Cell International

ISSN: 1475-2867

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