RNA m6A methylation regulators in liver cancer

Table 3 Functions of m6A ‘readers’ in liver cancer

Regulator	Effect on m6A modification	Expression change	(Refs.)
YTH domain family
YTHDF1	Enhances m6A-modified RNA translation	Up	^53,58
YTHDF2	Promotes m6A-modified RNA degradation	Up	^56,59
YTHDF3	Accelerates m6A-modified RNA translation and degradation	Up	^56,60
YTHDC1	Regulates m6A-modified RNA splicing and export	Up	⁵⁴
YTHDC2	Promotes m6A-modified RNA translation efficiency	Up	⁵³
HNRNP family
HNRNPC and HNRNPG	Regulates the abundance and alternative splicing of target genes	Up	⁶¹
HNRNPA2B1	Promotes the processing of primary miRNA	Up	^62,63
IGF2BP1-3	Stabilizes m6A-modified mRNA	Up	^64,65

m6A, N6-methyladenosine; miRNA, microRNA; YTH, YT521-B homology; YTHDF1, YTH domain family 1; YTHDC1, YTH domain containing 1; HNRNP, heterogeneous nuclear ribonucleoprotein protein; IGF2BP, insulin-like growth factor 2 mRNA binding protein

ISSN: 1475-2867