Fig. 5

RORα deletion promotes GC proliferation induced by 3PO and DHEA in vitro. A The colonies of GC cells were performed with colony formation assay. N=3. ^#P > 0.05. Vs. CON+Vehicle group in AGS cell. ^##P > 0.05. Vs. RORα-KO+Vehicle group in MKN-74 cell. B The absorbance value of RORα-KO GC cells treated with 3PO (25 µM) or DHEA (250 µM) according to time gradient through CCK-8 assay. N = 3. C The relative mRNA levels of E-cadherin, N-cadherin and Vimentin were detected by qPCR assay in RORα-KO GC cells treated with 3PO (25 µM) or DHEA (250 µM). N = 3. All data are represented as the mean ± standard deviation. Vehicle was DMSO. *P < 0.05, **P < 0.01, and ***P < 0.001. Vs. RORα-KO+Vehicle group. ⁺P < 0.05, ⁺⁺P < 0.01, and ⁺⁺⁺P < 0.001. Vs. CON+Vehicle group