Fig. 6

RORα inhibits G6PD and PFKFB3 gene expression through the recruitment of promoter in GC cells. A G6PD and PFKFB3 protein expression levels were detected by western blot in RORα-KO, CON, RORα-KO plus 3PO and RORα-KO plus DHEA GC cells. β-actin as a loading control. B G6PD and PFKFB3 mRNA levels were detected by q-PCR in lentiviral transfected GC cells. N = 3. C RORα was recruited to G6PD and PFKFB3 gene promoter in GC cells through Chip assay. N=3. All data are represented as the mean ± standard deviation. *P < 0.05, **P < 0.01, and ***P < 0.001