Fig. 8

Inhibition of glucose uptake improved fluorouracil chemoresistance in RORα-KO GC cells. A The GC cells were pretreated with 5mM or 50mM glucose for 24h, and then were treated with fluorouracil according to 0, 50, 100, 150 and 200 µg/ml concentration gradient. N = 3. B The GC cells were pretreated with 5 mM or 50 mM glucose for 24 h, and then were treated with fluorouracil (50 and 200 µg/ml concentration) according to time gradient. N = 3. The absorbance value was measured through CCK-8 assay. All data are represented as the mean ± standard deviation. Vehicle was DMSO. *P < 0.05, **P < 0.01, and ***P < 0.001