Interplay of miRNAs and lncRNAs in STAT3 signaling pathway in colorectal cancer progression

Table 2 MiRNAs indirectly target STAT3

MicroRNA	Up-/down	Oncogene/suppressor	Biological functions	Target gene	Ref.
MiR-216b	Down	Suppressor	proliferation, Migration, Invasion, Angiogenesis	HMGB1	[64]
MiR-214	Down	Suppressor	Proliferation, Migration, Invasion	HMGA1	[65]
MiR-452	Down	Suppressor	Inflammation	IL20RA	[66]
MiR-221/222	Up	Oncogene	Proliferation Colony formation	PDLIM2	[67]
MiR-34 A	Down	Suppressor	EMT Metastasis	PPP1R11	[68]
MiR-34a	Down	Suppressor	EMT Invasion	IL-6	[40]
MiR-320	Down	Suppressor	Inflammation Tumor formation Proliferation, Migration, Invasion	IL-6R	[69]
MiR-196b-5p	Up	Oncogene	Stemness, Chemoresistance	SOCS1 SOCS3	[70]
MiR-4449	Up	Oncogene	Cell proliferation	SOCS3	[71]
MiR-92a	Up	Oncogene	Stemness	SOCS3	[72]
MiR-543	Up	Oncogene	Proliferation, Metastasis	PIAS3	[73]
MiR-181b	Up	Oncogene	Warburg effect growth	PIAS3	[74]
MiR-375	Down	Suppressor	Proliferation	JAK2	[75]
MiR-4500	Up	Oncogene	Apoptosis	JAK2	[76]
MiR-128-3p	Up	Oncogene	Viability, Migration, Invasion, EMT	FOXO4	[77]
MiR-365a-3p	Down	Suppressor	Proliferation, Metastasis	ADAM10	[78]
MiR-21	Up	Oncogene	Inflammation	PTEN	[79]
MiR-34c-5p	Up	Oncogene	Proliferation Apoptosis	SIRT6	[80]
MiR-18a	Down	Suppressor	Growth, Proliferation	PIAS3	[81]

ISSN: 1475-2867