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Table 1 Cell lines treated with 5-flourouracil (5-FU) and oxaliplatin (OXL) at different concentrations (0–60 μM) for 72 h at 37 °C. IC50 values correspond to the concentration required to reduce cell growth by 50% compared to control cells. DMSO was used as positive control

From: RhoB expression associated with chemotherapy response and prognosis in colorectal cancer

Cell lines

IC50 values (µM) (Mean ± SEM)

5-FU

OXL

SW480

38.5 ± 0.8

21.9 ± 0.4

SW480-KO16

27.2 ± 0.5**

17.8 ± 0.3

SW480-KO55

25.9 ± 0.4**

18.8 ± 0.9

HCT116

51.2 ± 0.3

30.4 ± 0.5

HCT116-OE

54.8 ± 1.1

35.7 ± 0.7

  1. Data presented as mean ± SEM of 3 independent experiments (n = 3)
  2. *P < 0.05, **P < 0.01, compared to SW480 and HCT116
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Cancer Cell International

ISSN: 1475-2867

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