Identification of four snoRNAs (SNORD16, SNORA73B, SCARNA4, and SNORD49B) as novel non-invasive biomarkers for diagnosis of breast cancer

Table 1 Correlation between plasma snoRNAs expression and clinicopathologic characteristics of BC patients

Characteristics		SNORD16		SNORA73B		SCARNA4		SNORD49B
Characteristics		Case No.	P value	Case No.	P value	Case No.	P value	Case No.	P value
Age	≤ 51	122	0.8895	123	0.4033	122	0.8613	122	0.3928
Age	> 51	106	0.8895	111	0.4033	111	0.8613	108	0.3928
T stage	Tis	9	0.0350*	9	0.3952	9	0.1684	8	0.0090*
	T1	64		68		68		65
	T2	86		85		83		86
	T3	11		11		11		11
	T4	15		17		17		16
	unknown	43		44		45		44
Lymph node metastasis	N0	94	0.7340	95	0.4006	93	0.6994	94	0.6861
	N1	44		45		45		44
	N2	28		30		30		28
	N3	17		18		18		18
	Unknown	45		46		47		46
Distant metastasis	M0	171	0.6331	176	0.7222	174	0.7009	172	0.4625
	M1	12		12		12		12
	Unknown	45		46		47		46
TNM stage	Tis	8	0.0538	8	0.2053	8	0.2888	7	0.0180*
	I	42		43		43		43
	II	76		76		74		75
	III	42		46		46		44
	IV	9		9		9		9
	Unknown	51		52		53		52
ER	-	68	0.1855	68	0.0681	66	0.3334	67	0.3058
	+	154		160		161		157
	Unknown	6		6		6		6
PR	-	94	0.0807	96	0.0130*	94	0.1888	95	0.1015
	+	127		131		132		128
	Unknown	7		7		7		7
HER2	-	150	0.2007	156	0.1128	154	0.3975	151	0.2009
	+	65		64		65		66
	Unknown	13		14		14		13
Ki67	-	52	0.0504	54	0.0507	52	0.1296	52	0.0720
	+	170		174		175		172
	Unknown	6		6		6		6
Subtype	Luminal	126	0.9394	132	0.5234	130	0.9405	128	0.9071
	HER2-enriched	51		50		50		52
	Triple-negative	24		24		24		23
	Unknown	27		28		29		27

ISSN: 1475-2867