Fig. 4

ANP32B knockdown suppresses AML cells growth in vivo. A Schematic diagram illustrating the in vivo experimental setup. B Relevant bioluminescence imaging of the ANP32B knockdown group and control group on D12, D15, and D18 days. C Bioluminescent signal of organs at the endpoint in each group. D Mice in the ANP32B knockdown group exhibited prolonged survival time compared to the control group. E Histogram shows the bioluminescence signal values for both groups of mice at different time points. F Histogram shows the bioluminescence signal values of liver, spleen and bone. G Comparison of different weight of spleen between the two groups of mice. H H&E staining of organs from both groups of mice. I Representative IHC staining of ANP32B and C-MYC in spleen